On 15 August 1950 a magnitude 8.6 earthquake struck the border region between Assam, India, and Tibet, in the eastern Himalaya. Unlike most of the world's largest earthquakes, which occur where one tectonic plate dives beneath another at a subduction zone, this one ruptured deep within continental crust, where the Indian Plate collides head-on with Eurasia — making it the largest earthquake caused by continental collision ever measured by instruments.

Around 4,800 people died directly from the shaking and the huge landslides it triggered across the steep Himalayan terrain, which buried villages and blocked rivers. Some of the worst destruction hit sparsely populated mountain areas of Tibet and Assam, where entire hillsides gave way.

The most devastating aftermath came eight days later: a natural dam formed by landslide debris on the Subansiri River collapsed, releasing a sudden flood wave around 7 metres high that swept downstream and killed an estimated 1,500 more people in villages that had survived the earthquake itself.

Because it struck a remote, sparsely populated frontier region, the 1950 Assam–Tibet earthquake never became as widely known as other M8.5+ events, but seismologists still regard it as a critical benchmark for understanding the immense strain still stored along the Himalayan collision zone — strain that could eventually be released in a future 'great' earthquake along the range.